3-(5-fluoro-2-methylphenyl)-3-methylbutyric acid
3-(5-fluoro-2-methylphenyl)-3-methylbutanoic acid
CAS: 849353-56-6
Molecular Formula: C12H15FO2
3-(5-fluoro-2-methylphenyl)-3-methylbutyric acid - Names and Identifiers
3-(5-fluoro-2-methylphenyl)-3-methylbutyric acid - Physico-chemical Properties
| Molecular Formula | C12H15FO2 |
| Molar Mass | 210.24 |
3-(5-fluoro-2-methylphenyl)-3-methylbutyric acid - Introduction
3-(5-fluoro-2-methylphenyl)-3-methylaminoic acid is an organic compound whose chemical formula is C12H15FO2. The following is a detailed description of the properties, uses, preparation and safety information of the compound:
Nature:
-Appearance: 3-(5-fluoro-2-methylphenyl)-3-methylbutanoic acid is generally white crystal or crystalline powder.
-Melting point: approximately in the range of 77-81°C.
-Solubility: It can be dissolved in organic solvents (such as chloroform, ether and dichloromethane), but the solubility is low.
Use:
- 3-(5-fluoro-2-methylphenyl)-3-methylbutanoic acid is usually used as a drug intermediate and a raw material for the synthesis of drugs. It can be used as a synthetic intermediate of anti-inflammatory, analgesic, antidepressant and anxiolytic drugs, and has important drug research and development value.
Preparation Method:
The preparation method of -3-(5-fluoro-2-methylphenyl)-3-methylaminoic acid usually includes the following steps:
1.3-methyl butyric acid is reacted with bromo alkyl aromatic hydrocarbon to remove the ester protecting group to obtain the corresponding acid.
2. Use oxalic acid and cesium iodide catalyst for arylation reaction to replace the halogen in the reaction with fluoroalkyl aromatic hydrocarbon.
3. After crystallization, purification and drying, the target product 3-(5-fluoro-2-methylphenyl)-3-methylaminoic acid was obtained.
Safety Information:
- 3-(5-fluoro-2-methylphenyl)-3-methylaminoic acid has limited specific toxicity and safety data, so necessary safety measures should be taken during use.
-The compound may have certain toxic and ecological effects on the environment and should not be directly placed in the natural environment.
-Wear appropriate protective equipment such as protective gloves, goggles and face shields during handling and use.
-Avoid inhalation or skin contact, avoid ingestion. If contact with skin or eyes is made, rinse with plenty of water and seek medical attention.
-When handling the compound, it should be operated in accordance with the safe operating procedures for chemicals to avoid fire and high temperature.
Please note that before practical application or operation, relevant information and professional guidance should be consulted to ensure the safe use of this compound.
Nature:
-Appearance: 3-(5-fluoro-2-methylphenyl)-3-methylbutanoic acid is generally white crystal or crystalline powder.
-Melting point: approximately in the range of 77-81°C.
-Solubility: It can be dissolved in organic solvents (such as chloroform, ether and dichloromethane), but the solubility is low.
Use:
- 3-(5-fluoro-2-methylphenyl)-3-methylbutanoic acid is usually used as a drug intermediate and a raw material for the synthesis of drugs. It can be used as a synthetic intermediate of anti-inflammatory, analgesic, antidepressant and anxiolytic drugs, and has important drug research and development value.
Preparation Method:
The preparation method of -3-(5-fluoro-2-methylphenyl)-3-methylaminoic acid usually includes the following steps:
1.3-methyl butyric acid is reacted with bromo alkyl aromatic hydrocarbon to remove the ester protecting group to obtain the corresponding acid.
2. Use oxalic acid and cesium iodide catalyst for arylation reaction to replace the halogen in the reaction with fluoroalkyl aromatic hydrocarbon.
3. After crystallization, purification and drying, the target product 3-(5-fluoro-2-methylphenyl)-3-methylaminoic acid was obtained.
Safety Information:
- 3-(5-fluoro-2-methylphenyl)-3-methylaminoic acid has limited specific toxicity and safety data, so necessary safety measures should be taken during use.
-The compound may have certain toxic and ecological effects on the environment and should not be directly placed in the natural environment.
-Wear appropriate protective equipment such as protective gloves, goggles and face shields during handling and use.
-Avoid inhalation or skin contact, avoid ingestion. If contact with skin or eyes is made, rinse with plenty of water and seek medical attention.
-When handling the compound, it should be operated in accordance with the safe operating procedures for chemicals to avoid fire and high temperature.
Please note that before practical application or operation, relevant information and professional guidance should be consulted to ensure the safe use of this compound.
Last Update：2024-04-09 20:49:11
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